Description

2-Chloro-3-Fluoropyridine-4-Boronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique halogenated pyridine core makes it an indispensable reagent for constructing complex molecular architectures via cross-coupling reactions. This compound is primarily sought after by research scientists and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides that require halogenated pyridine scaffolds for enhanced bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic electronic materials, such as OLEDs and conductive polymers.
• Ligand and Catalyst Development: Employed to synthesize novel bidentate or tridentate ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and small-scale API development under cGMP guidelines.

Basic Information

Product Name	2-Chloro-3-Fluoropyridine-4-Boronic Acid
CAS No.	937595-71-6
Molecular Formula	C5H4BClFNO2
Molecular Weight	174.35 g/mol
Synonyms	(2-Chloro-3-fluoropyridin-4-yl)boronic acid; 2-Chloro-3-fluoro-4-pyridineboronic acid; 4-Borono-2-chloro-3-fluoropyridine; 2-Chloro-3-fluoropyridine-4-boronic acid pinacol ester (protected form); 2-Chloro-3-fluoro-4-pyridylboronic acid; 937595-71-6; B-(2-Chloro-3-fluoro-4-pyridinyl)boronic acid
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-3-Fluoropyridine-4-Boronic Acid is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and LC-MS are available for all shipments. Our quality commitment supports compliance with ISO 9001 standards and customer-specific requirements for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) to prevent moisture absorption and decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.