Description

1'-(tert-Butoxycarbonyl)-2H-Spiro[Benzofuran-3,4'-Piperidine]-2-Carboxylic Acid is a high-value, advanced pharmaceutical intermediate featuring a complex spirocyclic and piperidine scaffold. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for constructing novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting therapeutic areas such as central nervous system (CNS) disorders and oncology.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for CNS-targeting drugs.
• Medicinal Chemistry Research: Used in hit-to-lead optimization and structure-activity relationship (SAR) studies due to its complex, three-dimensional spirocyclic structure.
• Protease Inhibitor Development: The Boc-protected piperidine and carboxylic acid functionalities make it a valuable precursor for developing protease and enzyme inhibitors.
• Peptidomimetic Synthesis: Employed in the creation of peptidomimetics and constrained analogs to improve metabolic stability and bioavailability of peptide-based therapeutics.
• Chemical Biology Probes: Serves as a core structure for developing chemical probes to study biological pathways and protein function.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	1'-(tert-Butoxycarbonyl)-2H-Spiro[Benzofuran-3,4'-Piperidine]-2-Carboxylic Acid
CAS No.	937254-18-7
Molecular Formula	C18H23NO5
Molecular Weight	333.38 g/mol
Synonyms	Boc-Spiro(Benzofuran-3,4'-piperidine)-2-carboxylic Acid; 2H-Spiro[benzofuran-3,4'-piperidine]-2-carboxylic acid, 1'-(1,1-dimethylethyl) ester; 1'-Boc-2H-spiro[benzofuran-3,4'-piperidine]-2-carboxylic acid; 1'-tert-Butoxycarbonyl-2H-spiro[benzofuran-3,4'-piperidine]-2-carboxylic acid; 1'-Boc-2-carboxyspiro[benzofuran-3,4'-piperidine]; 937254-18-7; tert-Butyl 2-carboxy-2H-spiro[benzofuran-3,4'-piperidine]-1'-carboxylate
EINECS	Contact for details

Quality Control

Our 1'-(tert-Butoxycarbonyl)-2H-Spiro[Benzofuran-3,4'-Piperidine]-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are available for every lot. We support development projects requiring compliance with ICH guidelines and can supply material suitable for use under cGMP conditions for clinical trial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.