Description

1H-Pyrrolo[2,3-B]Pyridine, 5-Nitro-1-(Phenylsulfonyl)- is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 937012-11-8. This compound is a critical building block in the synthesis of complex heterocyclic molecules, offering a versatile nitro-substituted pyrrolopyridine scaffold for targeted drug discovery. It is essential for research and development chemists in the pharmaceutical and biotechnology sectors, particularly those focused on developing novel kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially for targeted cancer therapies.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and synthesizing novel protein kinase inhibitors due to its privileged pyrrolopyridine structure.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and selectivity.
• Chemical Biology Probes: Employed in the creation of molecular probes for studying enzyme function and cellular signaling pathways.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for clinical-stage compounds.
• Academic Research: Utilized in university and institutional labs for fundamental research in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 5-Nitro-1-(Phenylsulfonyl)-
CAS No.	937012-11-8
Molecular Formula	C13H9N3O4S
Molecular Weight	303.29 g/mol
Synonyms	5-Nitro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 1-(Phenylsulfonyl)-5-nitro-1H-pyrrolo[2,3-b]pyridine; 5-Nitro-1-tosyl-1H-pyrrolo[2,3-b]pyridine (common alias); 1-Benzenesulfonyl-5-nitro-1H-pyrrolo[2,3-b]pyridine; 5-Nitro-1H-pyrrolo[2,3-b]pyridine 1-(phenylsulfonyl) derivative; NPS-937012; 1H-Pyrrolo[2,3-b]pyridine, 5-nitro-1-(phenylsulfonyl)-; 937012-11-8
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 5-Nitro-1-(Phenylsulfonyl)- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive and easily oxidized; for long-term storage, consider maintaining under an inert atmosphere such as nitrogen or argon to preserve stability.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Single impurity ≤ 1.0%; Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.