Description

3-(Ethoxycarbonyl)-1-(2,3,5-Tri-o-Acetyl-β-D-Ribofuranosyl)-Pyridinium Triflate is a key protected nucleoside intermediate, specifically a nicotinamide riboside derivative, essential for advanced pharmaceutical synthesis. Its core value lies in providing a reactive, acetyl-protected ribose scaffold for the controlled construction of complex bioactive molecules, particularly in nucleotide and cofactor research. This high-purity building block is critically needed by R&D scientists and process chemists in the pharmaceutical, biotechnology, and fine chemical sectors for developing novel therapeutics, including potential NAD+ precursors and antiviral agents.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of Nicotinamide Riboside (NR) and its analogs, which are investigated for their role in cellular energy metabolism and as potential therapeutics.
• Nucleotide Chemistry: Serves as a protected precursor in the synthesis of modified nucleosides, nucleotides, and dinucleotides for biochemical and medicinal research.
• NAD+ Biosynthesis Research: Used in studies focusing on the enzymatic and chemical pathways of nicotinamide adenine dinucleotide (NAD+) biosynthesis and its boosting compounds.
• Process Development: Employed in scaling up the production of high-value nucleoside-based active pharmaceutical ingredients (APIs) under GMP-like conditions.
• Bioconjugation & Labeling: The reactive pyridinium moiety and protected sugars can be utilized for labeling or conjugating biomolecules in probe development.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) engaged in metabolic disease, aging, and epigenetics research.

Basic Information

Product Name	3-(Ethoxycarbonyl)-1-(2,3,5-Tri-o-Acetyl-β-D-Ribofuranosyl)-Pyridinium Triflate
CAS No.	936945-09-4
Molecular Formula	C21H26F3NO12S
Molecular Weight	597.50 g/mol
Synonyms	1-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-3-(ethoxycarbonyl)pyridinium trifluoromethanesulfonate; 3-Carbethoxy-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyridinium triflate; Nicotinamide Riboside Triflate Derivative; NR Triflate Intermediate; Ethyl 1-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)nicotinate Triflate; Protected Nicotinamide Riboside Triflate; 3-(Ethoxycarbonyl)-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyridinium trifluoromethanesulfonate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot is characterized using advanced analytical techniques including HPLC, NMR (1H & 13C), and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.