Description

Iodo-Peg3-Azide is a heterobifunctional crosslinker featuring an iodoacetamide group for thiol-specific conjugation and a terminal azide group for copper-catalyzed or strain-promoted click chemistry. This compound is essential for creating stable, site-specific bioconjugates, particularly in the development of antibody-drug conjugates (ADCs) and protein labeling. Researchers and process developers in the pharmaceutical, biotechnology, and diagnostic sectors rely on its precise reactivity to engineer next-generation therapeutics and analytical tools.

Application

• Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic payloads to monoclonal antibodies via cysteine residues.
• Protein and Peptide Labeling: Functionalization of thiol-containing biomolecules with fluorescent dyes, biotin, or other probes for detection and purification.
• Surface Immobilization: Crafting functionalized surfaces for biosensors or microarray platforms by reacting the azide group with alkyne-coated substrates.
• Polymer Modification: Introducing click-reactive handles onto polymers or dendrimers for creating advanced drug delivery systems.
• Chemical Biology Probes: Synthesis of activity-based probes to study enzyme function or protein-protein interactions in live cells.
• Lipid and Nanoparticle Functionalization: Conjugation of targeting ligands or stealth polymers to liposomes and nanoparticles for targeted therapy.

Basic Information

Product Name	Iodo-Peg3-Azide
CAS No.	936917-36-1
Molecular Formula	C11H21IN4O4
Molecular Weight	400.22 g/mol
Synonyms	1-Azido-3,6,9-trioxa-12-azatetradecan-14-oic acid 2,5-dioxo-1-pyrrolidinyl ester; 2,5-Dioxopyrrolidin-1-yl 1-azido-3,6,9-trioxa-12-azatetradecan-14-oate; Iodoacetamide-PEG3-Azide; Iodo-PEG3-N3; Azido-PEG3-Iodoacetamide; N-(Azido-PEG3)-N'-(iodoacetoxy)succinimide ester; NHS-PEG3-Iodoacetamide-Azide; 14-((2,5-Dioxopyrrolidin-1-yl)oxy)-1-azido-3,6,9-trioxa-12-azatetradecan-2-one
EINECS	Contact for details

Quality Control

Our Iodo-Peg3-Azide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and Mass Spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and development protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.