Description

3-Carboxy-4-Chlorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a crucial protected intermediate in modern organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, enabling the construction of complex biaryl structures. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for drug discovery and fine chemical production.

Application

• Pharmaceutical Intermediate: A key protected building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific biphenyl or heterobiaryl motifs.
• Material Science Research: Employed in the creation of organic electronic materials, such as those for OLEDs and organic photovoltaics, where precise molecular architecture is critical.
• Chemical Biology & Proteomics: Acts as a versatile handle in the synthesis of molecular probes, enzyme inhibitors, and bioconjugation reagents.
• Academic & Industrial R&D: A fundamental reagent for methodological development in synthetic organic chemistry and scale-up process optimization.

Basic Information

Product Name	3-Carboxy-4-Chlorophenylboronic Acid Pinacol Ester
CAS No.	936728-21-1
Molecular Formula	C13H16BClO4
Molecular Weight	282.53 g/mol
Synonyms	4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid; (4-Chloro-3-carboxyphenyl)boronic Acid Pinacol Ester; 2-(4-Chloro-3-carboxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Carboxy-4-chlorobenzeneboronic Acid Pinacol Ester; Pinacol (4-Chloro-3-carboxyphenyl)boronate
EINECS	Contact for details

Quality Control

Our 3-Carboxy-4-Chlorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance in cGMP and ISO 9001 environments for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.