Description

6-Fluorospiro[Chromene-2,4'-Piperidin]-4-(3H)-One Hydrochloride is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is essential for medicinal chemistry research, process development, and scale-up manufacturing within the pharmaceutical and biotechnology industries.

Application

• Key synthetic intermediate for the development of novel pharmaceutical candidates targeting neurological disorders.
• Critical building block in medicinal chemistry research and lead optimization programs.
• Used in the synthesis of potential API (Active Pharmaceutical Ingredient) precursors for preclinical and clinical studies.
• Valuable scaffold in drug discovery for creating libraries of spirocyclic compounds with therapeutic potential.
• Employed in process chemistry for route scouting and optimization of complex molecular architectures.
• Research chemical for academic and industrial studies investigating structure-activity relationships (SAR).

Basic Information

Item	Details
Product Name	6-Fluorospiro[Chromene-2,4'-Piperidin]-4-(3H)-One Hydrochloride
CAS No.	936648-40-7
Molecular Formula	C14H15FNO2·HCl
Molecular Weight	283.73 g/mol (Free base: 248.28 g/mol)
Synonyms	6-Fluorospiro[chromene-2,4'-piperidin]-4(3H)-one hydrochloride; 6-Fluoro-4H-spiro[chromene-2,4'-piperidine]-4-one hydrochloride; 6-Fluoro-1'-azaspiro[chromene-2,4'-piperidin]-4(3H)-one hydrochloride; 936648-40-7; UNII-9C3T6J8Q2K; 9C3T6J8Q2K; Spiro[chromene-2,4'-piperidin]-4(3H)-one, 6-fluoro-, hydrochloride; 6-Fluoro-3H-spiro[1-benzopyran-2,4'-piperidine]-4-one hydrochloride
EINECS	Contact for details

Quality Control

Our 6-Fluorospiro[Chromene-2,4'-Piperidin]-4-(3H)-One Hydrochloride is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.