Description

tert-Butyl 6-Amino-4-Oxospiro[Chroman-2,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and piperidine-based structure. This compound is of significant value for its role as a key building block in the synthesis of novel, biologically active molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, where precise chemical architecture is critical for drug discovery and process optimization.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potential drug candidates targeting central nervous system (CNS) disorders, pain management, or other therapeutic areas.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in early-stage drug discovery programs.
• API Development: Used in the research and process development of Active Pharmaceutical Ingredients (APIs) that incorporate spirocyclic or fused chroman-piperidine motifs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for the pharmaceutical industry.
• Chemical Biology Probes: Can be utilized to develop chemical probes for investigating biological pathways and protein functions in academic and industrial research settings.

Basic Information

Product Name	tert-Butyl 6-Amino-4-Oxospiro[Chroman-2,4'-Piperidine]-1'-Carboxylate
CAS No.	936648-34-9
Molecular Formula	C18H24N2O4
Molecular Weight	332.40 g/mol
Synonyms	1'-Boc-6-Amino-4-oxospiro[chroman-2,4'-piperidine]; tert-Butyl 6-amino-4-oxospiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylate; 6-Amino-4-oxospiro[chroman-2,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1,1-Dimethylethyl 6-amino-4-oxospiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylate; Boc-6-Amino-4-oxospiro[chroman-2,4'-piperidine]; Spiro[chroman-2,4'-piperidine]-1'-carboxylic acid, 6-amino-4-oxo-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Amino-4-Oxospiro[Chroman-2,4'-Piperidine]-1'-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert gas purging to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.