Description

tert-Butyl 7-Fluoro-4-Oxo-3,4-Dihydro-1'H-Spiro[Chromene-2,4'-Piperidine]-1'-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex spirocyclic and chromene-based molecular architecture. This compound is of significant value for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and oncological pathways. It is primarily needed by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in innovative drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of new chemical entities (NCEs) and proprietary drug candidates.
• Protease Inhibitor Research: Serves as a core scaffold for designing and optimizing molecules that modulate protease enzyme activity.
• Kinase Inhibitor Synthesis: Utilized in constructing potential kinase inhibitor libraries for oncology and anti-inflammatory drug discovery.
• Chemical Biology & Probe Development: Employed in creating molecular probes to study biological pathways and protein function.
• Process Chemistry & Route Scouting: Used by process chemists to develop and scale up efficient, cost-effective synthetic routes for target molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	tert-Butyl 7-Fluoro-4-Oxo-3,4-Dihydro-1'H-Spiro[Chromene-2,4'-Piperidine]-1'-Carboxylate
CAS No.	936648-33-8
Molecular Formula	C18H22FNO4
Molecular Weight	335.37 g/mol
Synonyms	1'-Boc-7-Fluoro-1'H-spiro[chromene-2,4'-piperidin]-4-one; 7-Fluoro-4-oxo-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylic acid tert-butyl ester; tert-Butyl 7-fluoro-4-oxo-1'H-spiro[chromene-2,4'-piperidine]-1'-carboxylate; 1,1-Dimethylethyl 7-fluoro-4-oxo-1'H-spiro[2H-1-benzopyran-2,4'-piperidine]-1'-carboxylate; 7-Fluoro-1'H-spiro[chromene-2,4'-piperidin]-4-one-1'-carboxylic acid tert-butyl ester; Boc-7-Fluoro-spiro[chromene-2,4'-piperidin]-4-one; Spiro[chromene-2,4'-piperidine] intermediate 936648-33-8
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 7-Fluoro-4-Oxo-3,4-Dihydro-1'H-Spiro[Chromene-2,4'-Piperidine]-1'-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and purity suitable for advanced research and development. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We are committed to meeting the exacting standards required for pharmaceutical R&D, and specifications can be aligned with client-specific requirements or general research-grade benchmarks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light) and should be handled with appropriate precautions for materials soluble in strong acid/organic solvent. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.