Description

n-(5-Chloro-2-Pyridinyl)-2-[(4-Cyanobenzoyl)Amino]-5-Methoxybenzamide Hydrochloride is a high-purity, non-nucleoside reverse transcriptase inhibitor (NNRTI) intermediate of significant pharmaceutical importance. This compound is valued for its role as a critical building block in the synthesis of advanced antiviral active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the development and production of next-generation HIV treatments and other antiviral therapies.

Application

• Pharmaceutical Intermediate: A key synthetic precursor for non-nucleoside reverse transcriptase inhibitor (NNRTI) class antiviral drugs.
• Antiviral API Synthesis: Used in the research, development, and commercial-scale manufacturing of active pharmaceutical ingredients targeting HIV and related viruses.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and the discovery of novel therapeutic agents.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of drug substances.
• Reference Standard: Can be utilized as a high-purity analytical reference standard for quality control and regulatory submissions.

Basic Information

Product Name	n-(5-Chloro-2-Pyridinyl)-2-[(4-Cyanobenzoyl)Amino]-5-Methoxybenzamide Hydrochloride
CAS No.	936539-81-0
Molecular Formula	C21H16ClN5O3 • HCl
Molecular Weight	474.75 g/mol
Synonyms	5-Methoxy-N-[2-[(4-cyanobenzoyl)amino]-5-methoxyphenyl]-2-pyridinecarboxamide hydrochloride; BILR 355 BS hydrochloride; R165335 Hydrochloride; BILR 355 BS (hydrochloride); BILR-355 hydrochloride; 2-[(4-Cyanobenzoyl)amino]-N-(5-chloro-2-pyridinyl)-5-methoxybenzamide hydrochloride; BILR355 hydrochloride; NNRTI Intermediate 936539-81-0
EINECS	Contact for details

Quality Control

Our n-(5-Chloro-2-Pyridinyl)-2-[(4-Cyanobenzoyl)Amino]-5-Methoxybenzamide Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation via IR and NMR, and residual solvent analysis to ensure it meets stringent specifications for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with every shipment, and we support regulatory filings with cGMP-compliant documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.