Description

tert-Butyl 4-(5-Aminopyridin-2-Ylamino)Piperidine-1-Carboxylate is a high-purity, protected piperidine derivative featuring both a Boc-protected amine and a free aminopyridine moiety. This compound serves as a critical pharmaceutical intermediate and building block in modern organic synthesis, enabling the construction of complex molecules with precise stereochemistry. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in oncology and CNS therapeutic areas.
• Kinase Inhibitor Development: Serves as a core scaffold for designing and synthesizing potent and selective kinase inhibitors.
• Chemical Biology Research: Used as a probe or building block in medicinal chemistry for structure-activity relationship (SAR) studies.
• Peptidomimetic Synthesis: The piperidine core and protected amine functionality make it valuable for creating peptide-like molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.
• Academic Research: Employed in university and institutional labs for methodological development and novel heterocycle synthesis.

Basic Information

Product Name	tert-Butyl 4-(5-Aminopyridin-2-Ylamino)Piperidine-1-Carboxylate
CAS No.	936368-89-7
Molecular Formula	C15H24N4O2
Molecular Weight	292.38 g/mol
Synonyms	1-Boc-4-[(5-Amino-2-pyridinyl)amino]piperidine; tert-Butyl 4-[(5-aminopyridin-2-yl)amino]piperidine-1-carboxylate; 4-[(5-Amino-2-pyridinyl)amino]-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester; 1,1-Dimethylethyl 4-[(5-amino-2-pyridinyl)amino]-1-piperidinecarboxylate; 936368-89-7; 4-(5-Aminopyridin-2-ylamino)piperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(5-Aminopyridin-2-Ylamino)Piperidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.