Description

(3,5-Difluoropyridin-2-Yl)Methanamine Hydrochloride is a high-purity, fluorinated pyridine derivative building block essential for modern pharmaceutical and agrochemical research and development. Its value lies in its role as a key synthetic intermediate, enabling the introduction of a functionalized amine group into complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for creating novel active ingredients, particularly in areas like kinase inhibitors and central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, especially for targeted therapies.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, leveraging the stability of the difluoropyridine moiety.
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds and probes used in biochemical assays and diagnostic research.
• Material Science: Potential monomer or precursor for specialty polymers and advanced organic materials.
• Ligand Synthesis: Used in the preparation of complex ligands for catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific target molecules under cGMP or research-grade conditions.

Basic Information

Product Name	(3,5-Difluoropyridin-2-Yl)Methanamine Hydrochloride
CAS No.	936363-97-2
Molecular Formula	C6H7ClF2N2
Molecular Weight	180.58 g/mol
Synonyms	2-(Aminomethyl)-3,5-difluoropyridine Hydrochloride; 1-(3,5-Difluoropyridin-2-yl)methanamine Hydrochloride; (3,5-Difluoro-2-pyridinyl)methanamine Hydrochloride; 2-(Aminomethyl)-3,5-difluoropyridine HCl; 3,5-Difluoropyridine-2-methanamine Hydrochloride; (3,5-Difluoropyridin-2-yl)methylamine Hydrochloride
EINECS	Contact for details

Quality Control

Our (3,5-Difluoropyridin-2-Yl)Methanamine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding R&D and scale-up processes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support development with custom synthesis and can provide material compliant with ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.