Description

4-Pyridinecarbonitrile, 3-[1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-Hydroxy-1-Methyl-3-(1H-1,2,4-Triazol-1-Yl)Propyl]-1H-Pyrazol-4-Yl]- is a high-purity, complex heterocyclic compound featuring a pyridinecarbonitrile core integrated with difluorophenyl, triazole, and pyrazole moieties. This advanced pharmaceutical intermediate is critical for the synthesis of novel antifungal agents, offering a key chiral building block for targeted drug development. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the discovery and production of next-generation therapeutic compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of potent antifungal APIs, particularly triazole-based therapeutics.
• Antifungal Drug Synthesis: Serves as a critical precursor in the multi-step synthesis of advanced azole antifungal agents targeting fungal CYP51 enzymes.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for discovering new bioactive molecules with improved efficacy and safety profiles.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Biochemical Research: May be utilized as a reference standard or probe in enzymatic assays and target validation studies related to fungal infections.

Basic Information

Product Name	4-Pyridinecarbonitrile, 3-[1-[(1R,2R)-2-(2,4-Difluorophenyl)-2-Hydroxy-1-Methyl-3-(1H-1,2,4-Triazol-1-Yl)Propyl]-1H-Pyrazol-4-Yl]-
CAS No.	936357-74-3
Molecular Formula	C21H18F2N6O
Molecular Weight	408.41 g/mol
Synonyms	3-(1-((1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl)-1H-pyrazol-4-yl)isonicotinonitrile; (1R,2R)-2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl-4-pyrazolyl-4-cyanopyridine; Isavuconazole Intermediate; Isavuconazole Key Intermediate; BAL4815 Intermediate; RO0094815 Intermediate; (2R,3R)-2-(2,4-Difluorophenyl)-3-(4-(4-cyanopyridin-3-yl)-1H-pyrazol-1-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict cGMP (current Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Every lot undergoes comprehensive analytical characterization using HPLC, GC, NMR, and MS to confirm identity, chiral purity, and chemical purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes. We support our clients' regulatory filings with comprehensive DMF (Drug Master File) support and stability data packages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is hygroscopic (moisture-sensitive); ensure containers are sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.