Description

5-Bromo-2-(3-Fluoro-Phenoxy)-Pyridine is a high-purity, advanced pharmaceutical intermediate characterized by its distinct halogenated pyridine and phenoxy ether structure. This compound is of significant commercial value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics. It is primarily sought after by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially kinase inhibitors targeting oncology and inflammatory diseases.
• Agrochemical Research: Serves as a structural motif in the development of new herbicides and pesticides, leveraging its halogenated aromatic system.
• Material Science: Used in the research and development of specialty polymers and liquid crystals, where its molecular architecture can influence material properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct more complex heterocyclic systems for various R&D applications.

Basic Information

Product Name	5-Bromo-2-(3-Fluoro-Phenoxy)-Pyridine
CAS No.	936343-48-5
Molecular Formula	C11H7BrFNO
Molecular Weight	268.08 g/mol
Synonyms	5-Bromo-2-(3-fluorophenoxy)pyridine; 2-(3-Fluorophenoxy)-5-bromopyridine; 936343-48-5; 5-Bromo-2-(3-fluoro-phenoxy)-pyridine; Pyridine, 5-bromo-2-(3-fluorophenoxy)-; 5-Brom-2-(3-fluor-phenoxy)-pyridin
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(3-Fluoro-Phenoxy)-Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with cGMP and ICH Q7 guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.