Description

3-((Trimethylsilyl)Ethynyl)Pyridin-2-Amine is a specialized organosilicon building block featuring a pyridine core functionalized with a trimethylsilyl-protected ethynyl group and an amine. This compound is valued for its role as a key intermediate in advanced organic synthesis, particularly in cross-coupling reactions and the construction of complex heterocyclic scaffolds. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and other small-molecule therapeutic programs.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its functional groups for structural diversity.
• Material Science Precursor: Serves as a monomer or linker in the development of advanced polymers, metal-organic frameworks (MOFs), and organic electronic materials.
• Cross-Coupling Reactions: The protected alkyne and amine groups make it a versatile reagent in Sonogashira, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions.
• Chemical Research: Employed in academic and industrial R&D for methodology development and the exploration of new synthetic pathways.
• Ligand Synthesis: Used as a precursor for creating novel nitrogen-containing ligands for catalysis.

Basic Information

Product Name	3-((Trimethylsilyl)Ethynyl)Pyridin-2-Amine
CAS No.	936342-23-3
Molecular Formula	C10H16N2Si
Molecular Weight	192.34 g/mol
Synonyms	2-Amino-3-((trimethylsilyl)ethynyl)pyridine; 3-(2-Trimethylsilylethynyl)pyridin-2-amine; 3-(Trimethylsilylethynyl)pyridin-2-amine; 2-Pyridinamine, 3-[(trimethylsilyl)ethynyl]-; 3-Ethynyl-2-aminopyridine, TMS-protected; TMS-protected 3-ethynyl-2-aminopyridine
EINECS	Contact for details

Quality Control

Our 3-((Trimethylsilyl)Ethynyl)Pyridin-2-Amine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.