Description

2,3-Dihydrospiro[Indene-1,4'-Piperidine]-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique spirocyclic structure that combines indene and piperidine moieties. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in developing new therapeutic agents, particularly within central nervous system (CNS) and other specialty drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of novel drug candidates.
• Medicinal Chemistry Research: Used as a sophisticated scaffold for structure-activity relationship (SAR) studies and lead optimization.
• API Synthesis: Serves as a core building block in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• CNS Drug Discovery: Particularly relevant for developing compounds targeting neurological and psychiatric disorders due to its structural features.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	2,3-Dihydrospiro[Indene-1,4'-Piperidine]-3-Carboxylic Acid
CAS No.	936138-16-8
Molecular Formula	C15H17NO2
Molecular Weight	243.30 g/mol
Synonyms	Spiro[indene-1,4'-piperidine]-3-carboxylic acid, 2,3-dihydro-; 2,3-Dihydro-1'H-spiro[indene-1,4'-piperidine]-3-carboxylic acid; 936138-16-8; 2,3-Dihydrospiro[indene-1,4'-piperidine]-3-carboxylic acid; Spiro[indene-1,4'-piperidine]-3-carboxylic acid, 2,3-dihydro- (9CI); 3-Carboxy-2,3-dihydrospiro[indene-1,4'-piperidine]; 2,3-Dihydro-1'H-spiro[indene-1,4'-piperidine]-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized and controlled using advanced analytical techniques to guarantee identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for all critical parameters are available upon request. Our quality management system supports development under cGMP guidelines as required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.