Description

Methyl (2R)-2-{[(tert-Butoxy)Carbonyl]Amino}-2-Cyclopropylacetate CAS NO 936097-43-7 is a high-purity, chiral amino acid derivative used as a critical building block in advanced organic synthesis. Its value lies in providing a protected, stereochemically defined cyclopropylglycine unit, which is essential for constructing complex molecules with precise three-dimensional architecture. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), especially peptidomimetics and protease inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel drug candidates, particularly those targeting viral proteases and other enzymes.
• Peptidomimetic Research: Used to incorporate the constrained cyclopropyl ring into peptide backbones to enhance metabolic stability and biological activity.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations to create enantiomerically pure compounds.
• API Development: Employed in the research and process development stages for new Active Pharmaceutical Ingredients requiring the (R)-2-amino-2-cyclopropylacetic acid motif.
• Chemical Biology Probes: Utilized in the design and synthesis of labeled or modified amino acids for studying biological mechanisms.
• Custom Synthesis & Contract Manufacturing: A requested building block for custom synthesis projects at laboratory, pilot, and commercial scales.

Basic Information

Product Name	Methyl (2R)-2-{[(tert-Butoxy)Carbonyl]Amino}-2-Cyclopropylacetate
CAS No.	936097-43-7
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	(R)-Methyl 2-((tert-butoxycarbonyl)amino)-2-cyclopropylacetate; Boc-(R)-Cyclopropylglycine-OMe; Methyl (R)-2-(Boc-amino)-2-cyclopropylacetate; (R)-2-(Boc-amino)-2-cyclopropylacetic acid methyl ester; (R)-2-((tert-Butoxycarbonyl)amino)-2-cyclopropylacetic acid methyl ester; (R)-Boc-Cpg-OMe; (2R)-2-[(tert-Butoxycarbonyl)amino]-2-cyclopropylethanoic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl (2R)-2-{[(tert-Butoxy)Carbonyl]Amino}-2-Cyclopropylacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.