Description

Azd 1480 CAS NO 935666-88-9 is a potent and selective small molecule inhibitor of the JAK/STAT signaling pathway. This compound is a critical research tool for investigating inflammatory and autoimmune disease mechanisms, as well as oncological pathways. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in drug discovery and preclinical studies.

Application

• Biomedical Research: A key reagent for studying the role of JAK/STAT signaling in cellular processes, inflammation, and immune response.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel therapeutics for autoimmune disorders such as rheumatoid arthritis and psoriasis.
• Oncology Research: Used to investigate the inhibition of STAT3 and STAT5 phosphorylation in various cancer cell lines and models.
• Academic Studies: Employed in university and institutional labs for fundamental research into cytokine signaling and transcriptional regulation.
• Preclinical Testing: Utilized in animal models to evaluate the efficacy and pharmacokinetics of JAK/STAT pathway inhibition.
• Biochemical Assay Development: Acts as a control compound in high-throughput screening (HTS) and enzymatic assay validation.

Basic Information

Product Name	Azd 1480
CAS No.	935666-88-9
Molecular Formula	C₂₀H₂₀N₆O₂
Molecular Weight	376.41 g/mol
Synonyms	AZD-1480; AZD1480; GSK-805; GSK805; N-(cyanomethyl)-4-[2-(4-morpholinyl)ethoxy]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-yl]benzamide; JAK Inhibitor AZD1480; 4-[2-(Morpholin-4-yl)ethoxy]-N-(4-pyrrolo[2,3-b]pyridin-3-yl-pyrimidin-2-yl)-N-(cyanomethyl)benzamide
EINECS	Contact for details

Quality Control

Azd 1480 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.