Description

3-Bromo-2,4-Difluorobenzoic Acid Methyl Ester is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound matters as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its specific halogen and fluorine substitution pattern enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the difluoro and bromo substituents contribute to biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and liquid crystals with unique electronic or optical properties.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination for carbon-carbon and carbon-heteroatom bond formation.
• Fluorine Chemistry Studies: Used as a model compound in academic and industrial research to study the effects of fluorine atoms on aromatic system reactivity and physicochemical properties.

Basic Information

Item	Detail
Product Name	3-Bromo-2,4-Difluorobenzoic Acid Methyl Ester
CAS No.	935534-49-9
Molecular Formula	C8H5BrF2O2
Molecular Weight	251.03 g/mol
Synonyms	Methyl 3-Bromo-2,4-difluorobenzoate; Benzoic acid, 3-bromo-2,4-difluoro-, methyl ester; 3-Bromo-2,4-difluorobenzoic acid methyl ester; Methyl 3-bromo-2,4-difluorobenzoate; 935534-49-9; 2,4-Difluoro-3-bromobenzoic acid methyl ester; 3-Bromo-2,4-difluorobenzoate methyl ester
EINECS	Contact for details

Quality Control

Our 3-Bromo-2,4-Difluorobenzoic Acid Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.