Description

2-(tert-Butyl-Dimethylsilanyloxy)-1-(4-Fluorophenyl)-Ethanone is a key protected intermediate in advanced organic synthesis, valued for its role in constructing complex molecular architectures. This compound matters because it provides a stable, silyl-protected ketone functionality that is crucial for multi-step synthetic routes, particularly in fine chemical and pharmaceutical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the production of active pharmaceutical ingredients (APIs) and other high-value fluorinated compounds.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel fluorinated drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced fluorinated pesticides and herbicides, where the fluorine atom enhances biological activity and stability.
• Material Science Research: Serves as a precursor for developing specialty polymers and advanced organic materials with tailored properties.
• Academic & R&D Laboratories: Employed in methodological studies and as a model substrate for developing new synthetic methodologies involving silyl protecting groups.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis organizations (CSOs) and CDMOs producing complex, fluorinated organic molecules on scale.

Basic Information

Product Name	2-(tert-Butyl-Dimethylsilanyloxy)-1-(4-Fluorophenyl)-Ethanone
CAS No.	935534-38-6
Molecular Formula	C14H21FO2Si
Molecular Weight	268.40 g/mol
Synonyms	1-(4-Fluorophenyl)-2-[(tert-butyldimethylsilyl)oxy]ethanone; 2-[(tert-Butyldimethylsilyl)oxy]-1-(4-fluorophenyl)ethanone; 4-Fluoro-2'-(tert-butyldimethylsilyloxy)acetophenone; TBDMS-protected 4-fluoro phenacyl alcohol; 2-(Tert-Butyl-Dimethyl-Silanyloxy)-1-(4-Fluoro-Phenyl)-Ethanone; 4-Fluorophenacyl tert-butyldimethylsilyl ether; 935534-38-6
EINECS	Contact for details

Quality Control

Our 2-(tert-Butyl-Dimethylsilanyloxy)-1-(4-Fluorophenyl)-Ethanone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.