Description

1-Piperidinecarboxylic Acid, 2-[1-[3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzoyl]-3-Hydroxy-3-Azetidinyl]-, 1,1-Dimethylethyl Ester, (2R)- is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, particularly for targeting specific biological pathways. It is primarily utilized by pharmaceutical manufacturers and contract research organizations (CROs) engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel, targeted small-molecule drug candidates.
• Kinase Inhibitor Research: Used in the R&D of potential kinase inhibitors for oncology and inflammatory diseases.
• Preclinical Development: Serves as a critical material for pharmacokinetic, pharmacodynamic, and toxicology studies.
• Process Chemistry: Employed in route scouting and optimization for scalable API manufacturing processes.
• Chemical Biology: Useful as a probe or precursor in studying enzyme function and cellular signaling pathways.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and validation.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 2-[1-[3,4-Difluoro-2-[(2-Fluoro-4-Iodophenyl)Amino]Benzoyl]-3-Hydroxy-3-Azetidinyl]-, 1,1-Dimethylethyl Ester, (2R)-
CAS No.	934665-56-2
Molecular Formula	C26H29F3IN3O4
Molecular Weight	631.43 g/mol
Synonyms	(2R)-tert-Butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate; (R)-tert-Butyl 2-(1-(3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)benzoyl)-3-hydroxyazetidin-3-yl)piperidine-1-carboxylate; UNII-6K6L8HZ2Q3; 6K6L8HZ2Q3; BMS-817378 intermediate; BMS 817378 intermediate; BMS-817378-01; tert-Butyl (2R)-2-[1-[[3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzoyl]-3-hydroxyazetidin-3-yl]piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our pharmaceutical-grade intermediates are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your internal specifications and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere or in a controlled environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.