Description

1-Azetidinecarboxylic Acid, 3-Methylene-, 1,1-Dimethylethyl Ester is a high-value, protected azetidine derivative serving as a critical building block in advanced organic synthesis. This compound is essential for medicinal chemistry research and the development of novel pharmaceutical agents, particularly in the creation of constrained peptidomimetics and bioactive molecules. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those targeting protease inhibition or requiring conformationally restricted scaffolds.
• Peptidomimetics Research: Used to introduce the azetidine ring, a four-membered nitrogen heterocycle, to mimic peptide bonds and enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides, fungicides, and insecticides with unique modes of action.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme function and biological pathways.
• Polymer Modification: Acts as a monomer or functionalizing agent for creating polymers with specific chemical or physical properties.

Basic Information

Product Name	1-Azetidinecarboxylic Acid, 3-Methylene-, 1,1-Dimethylethyl Ester
CAS No.	934664-41-2
Molecular Formula	C9H15NO2
Molecular Weight	169.22 g/mol
Synonyms	tert-Butyl 3-methyleneazetidine-1-carboxylate; 3-Methyleneazetidine-1-carboxylic acid tert-butyl ester; 1-Boc-3-methyleneazetidine; Boc-3-methyleneazetidine; Azetidine-1-carboxylic acid, 3-methylene-, 1,1-dimethylethyl ester; 3-Methylene-1-azetidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1-Azetidinecarboxylic Acid, 3-Methylene-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.