Description

Pentafluorophenyl 2-Thiomorpholin-4-Ylisonicotinate is a specialized heterocyclic building block and reagent designed for advanced synthetic chemistry applications. This compound is valued for its unique molecular architecture, which combines a pentafluorophenyl ester group with a thiomorpholine-substituted pyridine core, enabling selective reactivity. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, such as active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting neurological or oncological pathways.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging its fluorine content for enhanced bioactivity and environmental stability.
• Chemical Biology Probe Synthesis: Serves as a precursor for creating labeled compounds or affinity probes to study enzyme function and protein interactions.
• Material Science: Potential use in the development of advanced polymers or organic electronic materials due to its conjugated system and fluorine atoms.
• Cross-Coupling Reactions: Acts as an activated ester reagent in palladium-catalyzed or other metal-mediated coupling reactions to form carbon-heteroatom bonds.
• Peptide Mimetic Chemistry: Employed in the design and synthesis of peptidomimetics where the thiomorpholine moiety can mimic natural amino acid side chains.

Basic Information

Product Name	Pentafluorophenyl 2-Thiomorpholin-4-Ylisonicotinate
CAS No.	934570-42-0
Molecular Formula	C₁₆H₁₀F₅NO₂S
Molecular Weight	375.32 g/mol
Synonyms	2-Thiomorpholin-4-ylisonicotinic acid pentafluorophenyl ester; 4-Pyridinecarboxylic acid, 2-(4-thiomorpholinyl)-, 2,3,4,5,6-pentafluorophenyl ester; Pentafluorophenyl 2-(thiomorpholin-4-yl)isonicotinate; 2-(Thiomorpholin-4-yl)isonicotinic acid pentafluorophenyl ester; PFP 2-Thiomorpholin-4-ylisonicotinate; Pentafluorophenyl 2-(4-thiomorpholinyl)isonicotinate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and development. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing batch-specific results are available upon request. We adhere to a quality management system to ensure traceability and consistency for our customers in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.