Description

Pentafluorophenyl 6-Phenylnicotinate is a specialized fluorinated aromatic ester building block of significant interest in advanced organic synthesis. Its core value lies in the highly reactive pentafluorophenyl ester group, which serves as an efficient activating agent for amide bond formation and other coupling reactions under mild conditions. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Peptide Coupling Reagent: Used as an active ester for the efficient synthesis of peptides and amides, minimizing racemization.
• Pharmaceutical Intermediate: Serves as a key building block in the development of active pharmaceutical ingredients (APIs), particularly for introducing nicotinate or phenylpyridine motifs.
• Bioconjugation Chemistry: Employed for labeling biomolecules (proteins, antibodies) with fluorophores or other functional probes due to its selective reactivity with amines.
• Polymer & Materials Science: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers with unique thermal or surface properties.
• Agrochemical Synthesis: Utilized in the research and development of novel herbicides, fungicides, and insecticides.
• Ligand & Catalyst Development: Functions as a precursor for creating complex ligands used in catalytic systems, including those for asymmetric synthesis.

Basic Information

Product Name	Pentafluorophenyl 6-Phenylnicotinate
CAS No.	934570-41-9
Molecular Formula	C18H8F5NO2
Molecular Weight	365.26 g/mol
Synonyms	6-Phenylnicotinic Acid Pentafluorophenyl Ester; Pentafluorophenyl 6-Phenylpyridine-3-carboxylate; 2,3,4,5,6-Pentafluorophenyl 6-Phenylnicotinate; PFP 6-Phenylnicotinate; NSC 855065; 3-Pyridinecarboxylic Acid, 6-Phenyl-, 2,3,4,5,6-Pentafluorophenyl Ester
EINECS	Contact for details

Quality Control

Our Pentafluorophenyl 6-Phenylnicotinate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.