Description

2-(4-Methoxyphenyl)-4,4,6-Trimethyl-1,3,2-Dioxaborinane, also known as 4-(4,4,6-Trimethyl-1,3,2-Dioxaborinan-2-Yl)Anisole, is a high-value, moisture-sensitive organoboron reagent. This compound serves as a critical synthetic intermediate, prized for its stability and reactivity in cross-coupling reactions, which are foundational to modern organic synthesis. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity building blocks for constructing complex molecular architectures.

Application

This specialized boronic ester is a versatile reagent with primary applications in advanced synthetic chemistry. Key uses include:

• Suzuki-Miyaura Cross-Coupling Reactions: As a key coupling partner for the synthesis of biaryl and heterobiaryl structures prevalent in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: In the research and development of novel drug candidates, particularly those containing methoxy-substituted aromatic systems.
• Agrochemical Synthesis: For constructing complex molecules used in the development of new herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: As a precursor for creating novel ligands and organometallic catalysts.
• Material Science Research: In the synthesis of organic semiconductors, liquid crystals, and other functional organic materials.
• Chemical Biology Probes: For labeling and modifying biomolecules in research settings.

Basic Information

Product Name	2-(4-Methoxyphenyl)-4,4,6-Trimethyl-1,3,2-Dioxaborinane
CAS No.	934558-31-3
Molecular Formula	C14H21BO3
Molecular Weight	248.13 g/mol
Synonyms	4-(4,4,6-Trimethyl-1,3,2-dioxaborinan-2-yl)anisole; 2-(4-Methoxyphenyl)-4,4,6-trimethyl-1,3,2-dioxaborinane; 4-Methoxyphenyl-4,4,6-trimethyl-1,3,2-dioxaborinane; Anisole, 4-(4,4,6-trimethyl-1,3,2-dioxaborinan-2-yl)-; 4,4,6-Trimethyl-2-(4-methoxyphenyl)-1,3,2-dioxaborinane; (4-Methoxyphenyl)-4,4,6-trimethyl-1,3,2-dioxaborinane
EINECS	Contact for details

Quality Control

Our 2-(4-Methoxyphenyl)-4,4,6-Trimethyl-1,3,2-Dioxaborinane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, this material should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition and maintain optimal purity. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.