Description

6-Bromospiro[Chroman-2,1-Cyclobutan]-4-One is a specialized spirocyclic organic compound featuring a brominated chromanone scaffold fused to a cyclobutane ring. This unique molecular architecture makes it a valuable and versatile advanced pharmaceutical intermediate and key building block in synthetic organic chemistry. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular frameworks.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Research: Used as a building block for developing new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science: Acts as a monomer or cross-linking agent in the development of advanced polymers and organic electronic materials.
• Chemical Biology: Employed as a molecular probe or scaffold in drug discovery for fragment-based screening and target identification.
• Academic & Contract Research: Essential for methodological studies in organic synthesis, including spirocyclization and cross-coupling reaction research.
• Fine Chemical Synthesis: A key starting material for synthesizing complex natural product analogs and other high-value specialty chemicals.

Basic Information

Product Name	6-Bromospiro[Chroman-2,1-Cyclobutan]-4-One
CAS No.	934555-03-0
Molecular Formula	C12H11BrO2
Molecular Weight	267.12 g/mol
Synonyms	6-Bromo-1-oxaspiro[2.5]octane-4,8-dione (incorrect but common misnomer); 6-Bromo-4H-spiro[benzopyran-2,1'-cyclobutan]-4-one; 6-Bromospiro(chroman-2,1'-cyclobutan)-4-one; 6-Bromo-1-oxaspiro[2.5]oct-4-en-8-one derivative; Spiro[chroman-2,1-cyclobutan]-4-one, 6-bromo-; 934555-03-0; Bromospirochromanon
EINECS	Contact for details

Quality Control

Every batch of 6-Bromospiro[Chroman-2,1-Cyclobutan]-4-One is manufactured under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.