Description

tert-Butyl 4-Amino-3-Methylbenzoate is a high-purity, protected benzoic acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in the combination of a free aromatic amine group and a tert-butyl ester, offering orthogonal protection strategies and enabling precise molecular construction. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing substituted benzoic acid motifs.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides that require specific aromatic amine and ester functionalities.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating advanced organic electronic materials due to its stable aromatic structure.
• Peptide Mimetics & PROTACs: The tert-butyl ester group provides a convenient handle for coupling reactions in the design of complex bio-active molecules and targeted protein degraders.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized azo dyes and high-performance pigments where lightfastness and color stability are required.
• Cross-Coupling Reactions: The aromatic amine can be diazotized or further functionalized, making it a valuable substrate for Suzuki, Buchwald-Hartwig, and other metal-catalyzed coupling reactions.

Basic Information

Product Name	tert-Butyl 4-Amino-3-Methylbenzoate
CAS No.	934481-43-3
Molecular Formula	C12H17NO2
Molecular Weight	207.27 g/mol
Synonyms	4-Amino-3-methylbenzoic acid tert-butyl ester; Benzoic acid, 4-amino-3-methyl-, 1,1-dimethylethyl ester; tert-Butyl 4-amino-m-toluate; 3-Methyl-4-aminobenzoic acid tert-butyl ester; 1,1-Dimethylethyl 4-amino-3-methylbenzoate; 4-(tert-Butoxycarbonyl)-2-methylaniline; 2-Methyl-4-((tert-butoxy)carbonyl)aniline
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-Amino-3-Methylbenzoate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for synthetic applications. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which could affect product stability and performance in sensitive reactions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.