Description

Robatumumab is a fully human monoclonal antibody targeting the insulin-like growth factor-1 receptor (IGF-1R). This compound is of significant interest in advanced pharmaceutical research and development, particularly for its potential therapeutic applications. It is primarily utilized by biotechnology firms, pharmaceutical research organizations, and academic institutions engaged in oncology and targeted therapy studies. The product is supplied as a high-purity reference material to support critical preclinical and clinical-stage investigations.

Application

• Oncology Research: Primary application in the study of IGF-1R signaling pathways in various cancers, including sarcoma, breast cancer, and lung cancer.
• Therapeutic Antibody Development: Serves as a key reference standard or biological tool in the development of novel monoclonal antibody-based therapies.
• Biomarker & Mechanism of Action Studies: Used in in vitro and in vivo models to investigate drug resistance mechanisms and identify predictive biomarkers.
• Clinical Trial Support Material: Acts as a critical component in the manufacturing and quality control of materials for clinical trial applications.
• Cell Signaling & Molecular Biology: A vital reagent for studying the role of IGF-1R in cell proliferation, survival, and differentiation.

Basic Information

Product Name	Robatumumab
CAS No.	934235-44-6
Molecular Formula	Contact for details
Molecular Weight	Approx. 145 kDa
Synonyms	SCH 717454; Anti-IGF-1R Monoclonal Antibody (SCH 717454); Human Anti-IGF1R IgG1, κ; IGF-1R Inhibitor SCH 717454; Fully Human Anti-IGF-1R mAb; Robatumumab (SCH 717454); Monoclonal Antibody to Insulin-like Growth Factor 1 Receptor
EINECS	Contact for details

Quality Control

Our Robatumumab is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, potency, and consistency. Specifications align with standards appropriate for research and development use. A comprehensive Certificate of Analysis (COA) detailing purity (by SEC-HPLC and CE-SDS), endotoxin levels, sterility, and biological activity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. The product is hygroscopic (moisture-sensitive); ensure containers are sealed under controlled atmospheric conditions when not in use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or clear solution
Identification (SEC-HPLC / CE-SDS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 95% (Monomer)
Protein Concentration	As per COA (UV Absorbance)
Endotoxin	< 1.0 EU/mg (LAL test)
Biological Activity (Binding ELISA / Cell-based Assay)	Conforms to reference

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.