Description

Alacizumab Pegol is a PEGylated, humanized monoclonal antibody fragment designed for targeted therapeutic applications. This engineered biologic offers enhanced stability and extended plasma half-life, making it a valuable asset in advanced pharmaceutical development. It is primarily utilized by research institutions and biopharmaceutical companies engaged in the development of novel oncology and immunology treatments. The compound is supplied under stringent quality controls to ensure batch-to-batch consistency for critical research and pre-clinical studies.

Application

• Oncology Research: Investigation as a targeted therapeutic agent in various cancer models.
• Immunology Studies: Exploration of mechanisms involving specific antigen targeting and immune modulation.
• Biopharmaceutical R&D: Serves as a key intermediate or reference standard in the development of antibody-drug conjugates (ADCs) and other biologics.
• Pre-clinical Development: Used in pharmacokinetic, pharmacodynamic, and toxicology studies to evaluate efficacy and safety profiles.
• Process Development: Acts as a model molecule for optimizing PEGylation and downstream purification processes.

Basic Information

Item	Detail
Product Name	Alacizumab Pegol
CAS No.	934216-54-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Anti-VEGFR2 Fab-PEG; Pegylated Anti-KDR Fab Fragment; GC1008; CDP791; Anti-Kinase Insert Domain Receptor (KDR) Fab-PEG Conjugate; Humanized Anti-VEGFR2 Fab' Fragment Conjugated with Polyethylene Glycol
EINECS	Contact for details

Quality Control

Our Alacizumab Pegol is produced and tested under a quality management system to ensure it meets the exacting standards required for research and development. Each batch is characterized for identity, purity, potency, and PEGylation ratio using advanced analytical techniques. A comprehensive Certificate of Analysis (COA) detailing specifications and test results is provided with every shipment to guarantee traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under controlled conditions to maintain stability. For long-term storage, consider desiccation or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (SEC-HPLC)	≥ 95.0%
Protein Content (UV)	Contact for details
Endotoxin (LAL)	< 1.0 EU/mg
Sterility (Membrane Filtration)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.