Description

4-Chloro-2-Methoxy-3-Nitropyridine is a high-purity, multi-functional heterocyclic building block of significant importance in advanced organic synthesis. Its core value lies in its versatile reactivity, where the chloro, methoxy, and nitro substituents offer distinct, orthogonal sites for selective functionalization, enabling the construction of complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, serving as a key intermediate in the development of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its pyridine core for bioactivity.
• Material Science Research: Serves as a precursor for functionalized ligands and organic electronic materials due to its electron-deficient aromatic system.
• Cross-Coupling Reactions: The chloro substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form biaryl structures.
• Nucleophilic Aromatic Substitution: The nitro group activates the ring for nucleophilic displacement, allowing for the introduction of amines, alkoxides, and other nucleophiles.
• Chemical Library Development: Employed in combinatorial chemistry and high-throughput screening for the generation of diverse compound libraries in drug discovery programs.

Basic Information

Product Name	4-Chloro-2-Methoxy-3-Nitropyridine
CAS No.	934180-48-0
Molecular Formula	C6H5ClN2O3
Molecular Weight	188.57 g/mol
Synonyms	3-Nitro-4-chloro-2-methoxypyridine; 4-Chloro-2-methoxy-3-nitropyridine; 2-Methoxy-4-chloro-3-nitropyridine; Pyridine, 4-chloro-2-methoxy-3-nitro-; 934180-48-0; 4-Chloro-2-methoxy-3-nitro-pyridine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Methoxy-3-Nitropyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, open flames, and incompatible materials. For long-term storage, consider storage under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.