Description

(E)-4-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Vinyl)Phenol is a high-value, advanced pharmaceutical intermediate and building block featuring a vinylphenol core linked to a pinacol boronate ester. This compound matters for its critical role in modern synthetic chemistry, specifically in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and conjugated systems. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional organic molecules.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biphenyl or stilbene scaffolds.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group serves as a versatile handle for palladium-catalyzed coupling with aryl or vinyl halides, enabling carbon-carbon bond formation.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific phenolic or conjugated structures.
• Organic Electronic Materials: A precursor for constructing conjugated polymers or small molecules used in OLEDs, organic photovoltaics (OPVs), and sensors.
• Liquid Crystal and Advanced Material Research: The rigid, planar structure of the molecule makes it suitable for developing new liquid crystal phases and other functional materials.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes due to its modifiable phenol and boronate groups.

Basic Information

Product Name	(E)-4-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Vinyl)Phenol
CAS No.	933986-82-4
Molecular Formula	C14H19BO3
Molecular Weight	246.11 g/mol
Synonyms	4-[(E)-2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)ethenyl]phenol; 4-Vinylphenylboronic Acid Pinacol Ester; (E)-4-Styrylphenylboronic Acid Pinacol Ester; 4-[(E)-2-(Pinacolatoboryl)vinyl]phenol; 2-(4-Hydroxystyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 933986-82-4; 4-Hydroxy-trans-styrylboronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our (E)-4-(2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Vinyl)Phenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.