Description

4-Bromo-2-(Trifluoromethoxy)Benzoic Acid Methyl Ester is a high-value, multi-functional aromatic ester building block, distinguished by its bromine and trifluoromethoxy substituents. This compound is engineered to provide a versatile and reactive scaffold for advanced organic synthesis, enabling the construction of complex molecules with tailored properties. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores with enhanced lipophilicity and metabolic stability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethoxy group can improve biological activity and environmental profile.
• Liquid Crystal & OLED Material Research: Serves as a building block for advanced electronic materials, where its aromatic structure and halogen atoms contribute to desired electronic and mesomorphic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form biaryl and other complex structures.
• Functional Polymer Monomer: Can be incorporated into polymer backbones to impart specific characteristics like chemical resistance or altered refractive index.
• Chemical Biology & Probe Development: Utilized in the creation of molecular probes and tags for studying biological systems due to its derivatizable ester and halogen functional groups.

Basic Information

Product Name	4-Bromo-2-(Trifluoromethoxy)Benzoic Acid Methyl Ester
CAS No.	933785-18-3
Molecular Formula	C9H6BrF3O3
Molecular Weight	299.04 g/mol
Synonyms	Methyl 4-bromo-2-(trifluoromethoxy)benzoate; Benzoic acid, 4-bromo-2-(trifluoromethoxy)-, methyl ester; 4-Bromo-2-trifluoromethoxybenzoic acid methyl ester; 2-Trifluoromethoxy-4-bromobenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-2-(Trifluoromethoxy)Benzoic Acid Methyl Ester is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specification results is provided with each shipment. Our quality commitment supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The product is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.