Description

1-Piperidinecarboxylic Acid, 3-Hydroxy-4-(Methylamino)-, 1,1-Dimethylethyl Ester, (3R,4R)-Rel- is a high-purity, stereochemically defined chiral piperidine derivative. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) and a versatile building block for complex organic synthesis. It is essential for research and development in the pharmaceutical industry, particularly for the synthesis of active pharmaceutical ingredients (APIs) targeting neurological and cardiovascular systems.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a building block in stereoselective synthesis to introduce specific chiral centers.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and novel drug discovery programs.
• Process Chemistry Development: Used in the scale-up and optimization of synthetic routes for pharmaceutical manufacturing.
• Chemical Biology Probes: Acts as a precursor for developing labeled compounds and molecular probes for biological studies.
• Catalyst and Ligand Synthesis: Potential precursor for the development of chiral catalysts and ligands used in enantioselective transformations.

Basic Information

Product Name	1-Piperidinecarboxylic Acid, 3-Hydroxy-4-(Methylamino)-, 1,1-Dimethylethyl Ester, (3R,4R)-Rel-
CAS No.	933477-84-0
Molecular Formula	C12H24N2O3
Molecular Weight	244.33 g/mol
Synonyms	(3R,4R)-rel-3-Hydroxy-4-(methylamino)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl (3R,4R)-rel-3-hydroxy-4-(methylamino)piperidine-1-carboxylate; (3R,4R)-rel-N-Boc-3-hydroxy-4-(methylamino)piperidine; (3R,4R)-rel-1-Boc-3-hydroxy-4-(methylamino)piperidine; (3R,4R)-rel-3-Hydroxy-N-methyl-4-piperidinecarboxylic acid tert-butyl ester; (3R,4R)-rel-tert-Butyl 3-hydroxy-4-(methylamino)piperidine-1-carboxylate; (3R,4R)-rel-4-(Methylamino)-3-hydroxypiperidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1-Piperidinecarboxylic Acid, 3-Hydroxy-4-(Methylamino)-, 1,1-Dimethylethyl Ester, (3R,4R)-Rel- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and manufacturing. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% de (diastereomeric excess)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Single Maximum Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.