Description

6-Chloroisothiazolo[5,4-b]pyridine-3-carboxylic acid is a high-value, heterocyclic carboxylic acid derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique fused-ring structure, incorporating both isothiazole and pyridine motifs, makes it a versatile building block for constructing complex molecular architectures. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its heterocyclic scaffold for bioactivity.
• Ligand and Catalyst Synthesis: Serves as a starting material for creating specialized ligands used in transition metal catalysis and coordination chemistry.
• Material Science: Employed in the research of organic electronic materials, such as semiconductors and light-emitting components, due to its electron-deficient aromatic system.
• Chemical Biology Probe Development: Utilized as a core structure for designing molecular probes and inhibitors to study enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific heterocyclic acid.

Basic Information

Product Name	6-Chloroisothiazolo[5,4-b]pyridine-3-carboxylic Acid
CAS No.	932702-35-7
Molecular Formula	C7H3ClN2O2S
Molecular Weight	214.63 g/mol
Synonyms	6-Chloro-3-isothiazolo[5,4-b]pyridinecarboxylic acid; 6-Chloro-3H-isothiazolo[5,4-b]pyridine-3-carboxylic acid; 6-Chloro-isothiazolo[5,4-b]pyridine-3-carboxylic acid; 932702-35-7; 6-Chloroisothiazolo[5,4-b]pyridine-3-carboxylic acid; 6-Chloro-3-carboxyisothiazolo[5,4-b]pyridine
EINECS	Contact for details

Quality Control

Our production of 6-Chloroisothiazolo[5,4-b]pyridine-3-carboxylic acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment and NMR/IR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay, related substances, and residual solvents. We support cGMP compliance for advanced applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.