Description

Methyl 5-Bromo-2-Fluoronicotinate is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in enabling the precise construction of complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries who require reliable, high-quality intermediates for their synthetic routes.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and pesticides, leveraging the bioactivity of the fluoronicotinate scaffold.
• Material Science Precursor: Serves as a starting material for creating functionalized ligands and organic electronic materials.
• Chemical Research & Development: Employed in academic and industrial R&D for method development and exploring new chemical spaces via cross-coupling and functional group transformations.
• Liquid Crystal & OLED Material Synthesis: The bromo and fluoro substituents make it a valuable intermediate for constructing fluorinated aromatic cores used in electronic displays.

Basic Information

Product Name	Methyl 5-Bromo-2-Fluoronicotinate
CAS No.	931105-37-2
Molecular Formula	C7H5BrFNO2
Molecular Weight	234.02 g/mol
Synonyms	5-Bromo-2-fluoro-3-pyridinecarboxylic acid methyl ester; Methyl 5-bromo-2-fluoropyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 5-bromo-2-fluoro-, methyl ester; 5-Bromo-2-fluoronicotinic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-2-Fluoronicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing identity, purity, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.