Description

1-Cbz-3-Acetylsulfanyl-Pyrrolidine CAS NO 930299-97-1 is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrolidine scaffold. This compound is of significant value for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily sought after by R&D teams and process chemists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Protease Inhibitor Development: Used in research for creating inhibitors of cysteine proteases and other enzymes, relevant for antiviral and anticancer drug discovery.
• Peptidomimetic Chemistry: Serves as a constrained scaffold for designing peptidomimetics to improve metabolic stability and bioavailability of peptide-based drugs.
• Chemical Biology Probes: Employed in the development of activity-based probes (ABPs) for studying enzyme function and mechanism in biological systems.
• Library Synthesis for HTS: A valuable starting material for generating diverse compound libraries used in high-throughput screening (HTS) campaigns.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or non-GMP conditions.

Basic Information

Product Name	1-Cbz-3-Acetylsulfanyl-Pyrrolidine
CAS No.	930299-97-1
Molecular Formula	C14H17NO3S
Molecular Weight	279.35 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-3-(acetylthio)pyrrolidine; 3-(Acetylsulfanyl)-1-[(phenylmethoxy)carbonyl]pyrrolidine; 1-Carbobenzoxy-3-acetylthiopyrrolidine; 1-Cbz-3-acetylthio-pyrrolidine; N-Cbz-3-(Acetylthio)pyrrolidine; 3-Acetylthio-1-Cbz-pyrrolidine; Pyrrolidine, 1-[(phenylmethoxy)carbonyl]-3-(acetylthio)-; 930299-97-1
EINECS	Contact for details

Quality Control

Our 1-Cbz-3-Acetylsulfanyl-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment supports development from research to commercial scale, with the capability to supply material meeting relevant ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.