Description

n-Boc-8-Hydroxy-5-Azaspiro[3.5]Nonane is a sophisticated, high-purity spirocyclic building block used in advanced organic synthesis. This compound is valued for its role as a key intermediate in the development of novel pharmaceuticals and bioactive molecules, particularly those targeting the central nervous system. It is essential for medicinal chemists and R&D teams in pharmaceutical, agrochemical, and fine chemical industries seeking to construct complex nitrogen-containing heterocycles with precise stereochemistry.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of potential drug candidates, especially for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in scaffold hopping and library synthesis for structure-activity relationship (SAR) studies.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing linkers or warheads due to its spirocyclic and functionalized structure.
• Agrochemical Synthesis: Intermediate for creating novel active ingredients with spirocyclic architectures.
• Chemical Biology Probes: Utilized in the design of molecular probes to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds under cGMP conditions.

Basic Information

Product Name	n-Boc-8-Hydroxy-5-Azaspiro[3.5]Nonane
CAS No.	929971-93-7
Molecular Formula	C13H23NO3
Molecular Weight	241.33 g/mol
Synonyms	8-Hydroxy-5-azaspiro[3.5]nonane-5-carboxylic acid tert-butyl ester; tert-Butyl 8-hydroxy-5-azaspiro[3.5]nonane-5-carboxylate; 5-Azaspiro[3.5]nonan-8-ol, 5-(1,1-dimethylethoxy)carbonyl]-; 5-Boc-8-hydroxy-5-azaspiro[3.5]nonane; Boc-8-OH-5-azaspiro[3.5]nonane; 929971-93-7; 5-azaspiro[3.5]nonane-8-ol, N-Boc-protected.
EINECS	Contact for details

Quality Control

Our n-Boc-8-Hydroxy-5-Azaspiro[3.5]Nonane is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments. Our quality commitment supports applications from research to pre-clinical development scales.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.