Description

1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 1-[Tris(1-Methylethyl)Silyl]- is a high-value, organosilicon-protected heterocyclic carboxylic acid derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary commercial value lies in enabling complex molecular construction, particularly for pharmaceutical research and development where precise functional group manipulation is required. This compound is essential for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and specialty chemical industries seeking to build novel nitrogen-containing heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new active ingredients with complex heterocyclic structures for crop protection.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of advanced organic electronic materials.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and exploration of new chemical space.
• Peptidomimetics & Bioisosteres: The pyrrolopyridine core is a valuable bioisostere for indole or other aromatic systems in medicinal chemistry programs.
• Protecting Group Strategy: The tris(isopropyl)silyl (TIPS) group provides steric protection for the pyrrole nitrogen, enabling selective downstream reactions.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 1-[Tris(1-Methylethyl)Silyl]-
CAS No.	929691-26-9
Molecular Formula	C17H26N2O2Si
Molecular Weight	318.49 g/mol
Synonyms	1-(Triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; 1-TIPS-7-azaindole-5-carboxylic acid; 1-[(Triisopropylsilyl)]-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid; 5-Carboxy-1-TIPS-7-azaindole; 1-TIPS-7-Aza-indole-5-carboxylic Acid; 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid, 1-(triisopropylsilyl)-; 929691-26-9
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine-5-Carboxylic Acid, 1-[Tris(1-Methylethyl)Silyl]- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity for research and scale-up applications. All materials are characterized by advanced analytical techniques including HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing lot-specific results are provided with every shipment, and we support compliance with relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.