Description

tert-Butyl 5-Bromo-1H-Pyrazolo[3,4-C]pyridine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a brominated pyrazolopyridine core protected by a tert-butoxycarbonyl (Boc) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel drug candidates. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers targeting oncology, CNS disorders, and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small molecule kinase inhibitors and other targeted therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization campaigns due to its reactive bromine handle and protected nitrogen.
• Cross-Coupling Reactions: The bromine substituent enables pivotal metal-catalyzed cross-coupling reactions, such as Suzuki, Negishi, and Buchwald-Hartwig amination, for introducing diverse functional groups.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a component for constructing E3 ligase ligands or linker segments in bifunctional degrader molecules.
• Chemical Biology Probes: Utilized in the development of chemical probes for studying enzyme function and cellular pathways.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the custom synthesis of complex molecules for clients.

Basic Information

Product Name	tert-Butyl 5-Bromo-1H-Pyrazolo[3,4-C]pyridine-1-carboxylate
CAS No.	929617-41-4
Molecular Formula	C11H12BrN3O2
Molecular Weight	298.14 g/mol
Synonyms	5-Bromo-1H-pyrazolo[3,4-c]pyridine-1-carboxylic acid tert-butyl ester; 1-Boc-5-bromo-1H-pyrazolo[3,4-c]pyridine; tert-Butyl 5-bromo-1H-pyrazolo[3,4-c]pyridine-1-carboxylate; 5-Bromo-1-(tert-butoxycarbonyl)-1H-pyrazolo[3,4-c]pyridine; 1H-Pyrazolo[3,4-c]pyridine-1-carboxylic acid, 5-bromo-, 1,1-dimethylethyl ester; 929617-41-4; Boc-5-Br-Pyrazolopyridine
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Bromo-1H-Pyrazolo[3,4-C]pyridine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive; prolonged exposure to light should be avoided. Keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.