Description

5-Fluoro-3-Iodo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine is a high-value, multi-functionalized heterocyclic building block designed for advanced synthetic chemistry. This compound matters because it provides a protected pyrrolopyridine scaffold with orthogonal halogen handles, enabling precise, sequential cross-coupling reactions for the construction of complex molecular architectures. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of novel active ingredients, as well as by specialty chemical manufacturers developing advanced materials and ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, anticancer agents, and other small-molecule therapeutics targeting challenging biological pathways.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators that require halogenated heterocyclic cores.
• Material Science: Serves as a precursor for organic electronic materials, such as OLED emitters and charge-transport molecules, where the fused ring system and halogens allow for fine-tuning of electronic properties.
• Catalyst & Ligand Development: Employed in the creation of sophisticated nitrogen-containing ligands for transition metal catalysis, leveraging the pyrrolopyridine nitrogen atoms for metal coordination.
• Chemical Biology Probes: Utilized to build fluorescent tags or photoaffinity labels for studying protein function and cellular processes.
• Academic & Contract Research: A versatile tool for methodology development in organic synthesis, particularly in palladium-catalyzed cross-coupling and C-H functionalization reactions.

Basic Information

Product Name	5-Fluoro-3-Iodo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine
CAS No.	928653-76-3
Molecular Formula	C17H26FIN2Si
Molecular Weight	432.39 g/mol
Synonyms	1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-3-iodo-1-[(1,1-dimethylethyl)dimethylsilyl]-; 5-Fluoro-3-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine; 1-TIPS-5-fluoro-3-iodo-7-azaindole; TIPS-Protected 5-Fluoro-3-iodo-7-azaindole; 5-F-3-I-1-TIPS-7-Azaindole; 928653-76-3; 5-Fluoro-3-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our 5-Fluoro-3-Iodo-1-Triisopropylsilanyl-1H-Pyrrolo[2,3-B]Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and scale-up applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing purity, identity, and impurity profiles as confirmed by advanced analytical techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.