Description

6-(1,4-Dioxa-8-Azaspiro[4.5]Dec-8-Yl)-3-Pyridinyl Boronic Acid is a sophisticated boronic acid derivative featuring a spirocyclic ketal-protected piperidine moiety, making it a valuable advanced pharmaceutical intermediate for modern drug discovery. Its primary value lies in its role as a key coupling partner in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl scaffolds. This compound is essential for medicinal chemistry research and process development teams in the pharmaceutical and agrochemical industries seeking to synthesize novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of drug candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Suzuki-Miyaura Cross-Coupling Reagent: Used to form carbon-carbon bonds between the pyridinyl ring and various aryl/heteroaryl halides, enabling library synthesis for high-throughput screening.
• Agrochemical Research: Employed in the development of novel herbicides, fungicides, and insecticides with complex heterocyclic structures.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of organic electronic materials and metal-organic frameworks (MOFs).
• Chemical Biology Probe Synthesis: Utilized to create tagged molecules for studying protein-ligand interactions and biological pathways.
• Process Chemistry & Scale-Up: Supports the development of robust, scalable synthetic routes from milligram to kilogram scale for clinical trial material production.

Basic Information

Product Name	6-(1,4-Dioxa-8-Azaspiro[4.5]Dec-8-Yl)-3-Pyridinyl Boronic Acid
CAS No.	928160-90-1
Molecular Formula	C15H21BN2O4
Molecular Weight	304.15 g/mol
Synonyms	(6-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)pyridin-3-yl)boronic acid; 3-Pyridineboronic acid, 6-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-; 6-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)pyridin-3-ylboronic acid; 6-(1,4-Dioxa-8-azaspiro[4.5]dec-8-yl)-3-pyridinylboronic acid; 6-(1,4-Dioxa-8-azaspiro[4.5]decan-8-yl)-3-pyridineboronic acid; Boronic acid, B-[6-(1,4-dioxa-8-azaspiro[4.5]dec-8-yl)-3-pyridinyl]-; 928160-90-1; Spirocyclic piperidine-protected pyridinyl boronic acid
EINECS	Contact for details

Quality Control

Our 6-(1,4-Dioxa-8-Azaspiro[4.5]Dec-8-Yl)-3-Pyridinyl Boronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency for research and development. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR spectroscopy for structural confirmation, and residual solvent testing. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC, Area %)	≥95.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.