Description

1,2-Pyrrolidinedicarboxylic Acid, 4-Methylene-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2S)- is a high-purity, chiral building block of significant importance in advanced organic synthesis. Its core value lies in its role as a protected derivative of (S)-4-methylenepyroglutamic acid, offering a stereochemically defined scaffold for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly for the development of novel peptide-based therapeutics and enzyme inhibitors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for protease inhibitors and other targeted therapies.
• Peptidomimetic Synthesis: Serves as a critical building block for creating peptidomimetics and constrained peptides, which are designed to enhance metabolic stability and bioavailability.
• Bioconjugation Chemistry: Used in the preparation of labeled compounds and probes for biochemical and diagnostic applications, leveraging the reactive methylene and protected carboxylic acid functionalities.
• Asymmetric Synthesis: Employed as a starting material or intermediate in asymmetric catalytic processes to introduce the (S)-configured pyroglutamate core into more complex molecular architectures.
• Chemical Biology Research: Utilized in the study of enzyme-substrate interactions and the development of activity-based probes for profiling enzymatic activity.

Basic Information

Product Name	1,2-Pyrrolidinedicarboxylic Acid, 4-Methylene-, 1-(9H-Fluoren-9-Ylmethyl) Ester, (2S)-
CAS No.	928063-67-6
Molecular Formula	C₂₂H₁₉NO₄
Molecular Weight	361.39 g/mol
Synonyms	(2S)-1-[(9H-Fluoren-9-yl)methyl] 4-methylenepyrrolidine-1,2-dicarboxylate; (S)-1-Fmoc-4-methylenepyroglutamic acid; Fmoc-(S)-4-methylenepyroglutamic acid; (S)-4-Methylene-1-(9H-fluoren-9-ylmethyl) pyrrolidine-1,2-dicarboxylate; (2S)-4-Methylene-1-[(9H-fluoren-9-yl)methyl] 1,2-pyrrolidinedicarboxylate; (S)-1-Fmoc-4-methylenepyroglutamate; Fmoc-4MepGlu-OH; (S)-1-(Fmoc)-4-methylenepyroglutamic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material that meets high-purity specifications suitable for research and cGMP manufacturing. Certificates of Analysis (COA) detailing identity, purity, and chiral integrity are available upon request. Our quality management system supports traceability and consistency for critical pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.