Description

1,8-Diazaspiro[4.5]Decane-8-Carboxylic Acid, Phenylmethyl Ester, (Hydrochloride) (1:1) is a high-purity, advanced pharmaceutical intermediate of significant importance in modern organic synthesis. This compound serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex spirocyclic and heterocyclic architectures. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of innovative drug candidates, where consistent quality and reliable supply are paramount.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those with spirocyclic amine structures.
• API Development: Used in research and development for creating new Active Pharmaceutical Ingredients (APIs) targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Employed as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Chemical Synthesis: Acts as a protected amine building block in multi-step organic synthesis, facilitating the construction of complex molecular frameworks.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	1,8-Diazaspiro[4.5]Decane-8-Carboxylic Acid, Phenylmethyl Ester, (Hydrochloride) (1:1)
CAS No.	928034-35-9
Molecular Formula	C16H22N2O2 • HCl
Molecular Weight	310.82 g/mol
Synonyms	Benzyl 1,8-diazaspiro[4.5]decane-8-carboxylate hydrochloride; 8-(Benzyloxycarbonyl)-1,8-diazaspiro[4.5]decane hydrochloride; 1,8-Diazaspiro[4.5]decane-8-carboxylic acid benzyl ester hydrochloride; Cbz-1,8-Diazaspiro[4.5]decane hydrochloride; Z-1,8-Diazaspiro[4.5]decane hydrochloride; 1,8-Diazaspiro[4.5]decane-8-carboxylate benzyl ester hydrochloride; 8-Carbobenzoxy-1,8-diazaspiro[4.5]decane hydrochloride
EINECS	Contact for details

Quality Control

Our 1,8-Diazaspiro[4.5]Decane-8-Carboxylic Acid, Phenylmethyl Ester, (Hydrochloride) (1:1) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.