Description

Pentafluorophenyl 6-Thien-2-Ylnicotinate is a specialized heterocyclic building block and activated ester, primarily utilized as a key intermediate in advanced organic synthesis. This compound matters for its role in facilitating efficient coupling reactions, particularly in the development of complex molecules for pharmaceutical and materials science research. It is needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who are engaged in creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting various disease pathways.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products, including herbicides and fungicides.
• Polymer & Materials Science: Serves as a monomer or functionalization agent in the creation of advanced polymers with specific electronic or optical properties.
• Bioconjugation & Probe Synthesis: The activated pentafluorophenyl ester group is effective for labeling biomolecules (proteins, peptides) and synthesizing fluorescent or affinity probes.
• Ligand & Catalyst Development: Employed in the preparation of novel ligands for catalysis or metal-organic frameworks (MOFs).
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting fundamental research in synthetic organic chemistry.

Basic Information

Product Name	Pentafluorophenyl 6-Thien-2-Ylnicotinate
CAS No.	926921-59-7
Molecular Formula	C16H6F5NO2S
Molecular Weight	371.28 g/mol
Synonyms	6-(Thiophen-2-yl)nicotinic acid pentafluorophenyl ester; Pentafluorophenyl 6-(thiophen-2-yl)nicotinate; 2,3,4,5,6-Pentafluorophenyl 6-(thiophen-2-yl)pyridine-3-carboxylate; 6-(2-Thienyl)-3-pyridinecarboxylic acid 2,3,4,5,6-pentafluorophenyl ester; PFP 6-Thien-2-Ylnicotinate; Pentafluorophenyl 6-(2-thienyl)nicotinate; Activated Ester of 6-(Thiophen-2-yl)nicotinic Acid
EINECS	Contact for details

Quality Control

Our Pentafluorophenyl 6-Thien-2-Ylnicotinate is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance as a synthetic intermediate. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.