Description

Pentafluorophenyl 3-(1,3-Thiazol-2-Yl)Benzoate is a specialized fluorinated aromatic ester derivative, serving as a high-value synthetic intermediate and building block in advanced organic chemistry. Its core value lies in the unique reactivity of the pentafluorophenyl (PFP) ester group, which is an excellent leaving group for amide and peptide bond formation under mild conditions, often used in coupling reagents and active ester methodologies. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional polymers. Its structure, incorporating both a fluorinated moiety and a thiazole heterocycle, makes it particularly valuable for creating compounds with enhanced bioavailability, metabolic stability, and specific electronic properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in constructing complex amides and peptides.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that leverage the thiazole and fluorinated aromatic motifs for bioactivity.
• Peptide Coupling Reagent: Acts as an active ester component in peptide synthesis, facilitating efficient amide bond formation with reduced racemization.
• Material Science Precursor: Serves as a monomer or cross-linking agent for synthesizing specialty polymers with unique thermal, optical, or surface properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and protein labeling.
• Ligand Synthesis for Catalysis: Intermediate for preparing sophisticated ligands used in transition metal catalysis, including asymmetric synthesis.

Basic Information

Item	Details
Product Name	Pentafluorophenyl 3-(1,3-Thiazol-2-Yl)Benzoate
CAS No.	926921-55-3
Molecular Formula	C18H8F5NO2S
Molecular Weight	397.32 g/mol
Synonyms	3-(1,3-Thiazol-2-yl)benzoic acid pentafluorophenyl ester; Pentafluorophenyl 3-(thiazol-2-yl)benzoate; 2,3,4,5,6-Pentafluorophenyl 3-(1,3-thiazol-2-yl)benzoate; PFP 3-(Thiazol-2-yl)benzoate; PFP Ester of 3-(2-Thiazolyl)benzoic Acid; Benzoic acid, 3-(2-thiazolyl)-, 2,3,4,5,6-pentafluorophenyl ester; CAS 926921-55-3
EINECS	Contact for details

Quality Control

Every batch of Pentafluorophenyl 3-(1,3-Thiazol-2-Yl)Benzoate is manufactured and tested under a strict quality management system to ensure high purity, consistency, and traceability. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity, ensuring compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.