Description

1-(3,5-Difluorophenyl)-5-Oxopyrrolidine-3-Carboxylic Acid is a high-purity fluorinated pyrrolidone derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in enabling the synthesis of novel, potent active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability. This compound is essential for research and development chemists and manufacturers in the pharmaceutical and agrochemical industries, particularly those focused on developing new central nervous system (CNS) and anti-inflammatory therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly for neurological and psychiatric disorders.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, leveraging the fluorinated aromatic system for improved activity.
• Chemical Biology Probe Synthesis: Employed in creating labeled compounds and molecular probes for studying biological pathways and target engagement.
• Material Science Precursor: Acts as a monomer or functionalizing agent in the development of specialized polymers with unique thermal or chemical resistance properties.
• Contract Research & Development (CRO/CMO): Supplied to research organizations and custom synthesis facilities for client-directed projects.
• Academic Research: Utilized in university and institutional labs for methodological development and exploratory synthesis in medicinal chemistry.

Basic Information

Product Name	1-(3,5-Difluorophenyl)-5-Oxopyrrolidine-3-Carboxylic Acid
CAS No.	926229-10-9
Molecular Formula	C11H9F2NO3
Molecular Weight	241.19 g/mol
Synonyms	3-Carboxy-1-(3,5-difluorophenyl)-2-pyrrolidinone; 1-(3,5-Difluorophenyl)-5-oxo-3-pyrrolidinecarboxylic acid; 5-Oxo-1-(3,5-difluorophenyl)pyrrolidine-3-carboxylic acid; 3-Pyrrolidinecarboxylic acid, 1-(3,5-difluorophenyl)-5-oxo-; Difluorophenyl Oxopyrrolidine Carboxylic Acid; DFPOA; (3,5-Difluorophenyl)-5-oxopyrrolidine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 1-(3,5-Difluorophenyl)-5-Oxopyrrolidine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider using desiccants or storing under an inert atmosphere to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.