Description

6-(Difluoromethyl)-4-Methyl-1H-Pyrazolo[3,4-B]Pyridin-3-Amine (Saltdata: Free) is a high-purity, advanced pharmaceutical intermediate belonging to the pyrazolopyridine class of heterocyclic compounds. Its core value lies in its role as a critical building block for the synthesis of novel, small-molecule drug candidates, particularly in oncology and kinase inhibitor research. This compound is essential for medicinal chemistry R&D teams and process development chemists in the pharmaceutical and biotechnology industries seeking to develop next-generation therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors and other biologically active molecules.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Process Chemistry Development: Serves as a starting material for scaling up synthetic routes under current Good Manufacturing Practice (cGMP) conditions.
• Biochemical Tool Compound: Utilized in vitro and in vivo to study specific biological pathways and validate novel drug targets.
• Agrochemical Research: Potential application as a scaffold for developing new crop protection agents with novel modes of action.

Basic Information

Product Name	6-(Difluoromethyl)-4-Methyl-1H-Pyrazolo[3,4-B]Pyridin-3-Amine (Saltdata: Free)
CAS No.	925146-05-0
Molecular Formula	C8H8F2N4
Molecular Weight	198.17 g/mol
Synonyms	6-(Difluoromethyl)-4-methyl-1H-pyrazolo[3,4-b]pyridin-3-amine; 4-Methyl-6-(difluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine; 3-Amino-6-(difluoromethyl)-4-methyl-1H-pyrazolo[3,4-b]pyridine; 925146-05-0; 6-Difluoromethyl-4-methyl-1H-pyrazolo[3,4-b]pyridin-3-ylamine; 1H-Pyrazolo[3,4-b]pyridin-3-amine, 6-(difluoromethyl)-4-methyl-
EINECS	Contact for details

Quality Control

Every batch of 6-(Difluoromethyl)-4-Methyl-1H-Pyrazolo[3,4-B]Pyridin-3-Amine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the stringent requirements for pharmaceutical development. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥95% by HPLC), and impurity profile is supplied with each shipment to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Area%)	≥ 97.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.