Description

3-[4-(1H-Tetrazol-1-Yl)Phenyl]Propanoic Acid is a high-value heterocyclic carboxylic acid derivative, serving as a critical synthetic intermediate and building block in advanced organic chemistry. Its unique structure, featuring both a tetrazole ring and a phenylpropanoic acid moiety, makes it a versatile precursor for developing novel active pharmaceutical ingredients (APIs) and functional materials. This compound is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and material science sectors for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of sartan-class antihypertensive drugs (e.g., Valsartan, Losartan analogs) and other bioactive molecules targeting angiotensin II receptors.
• Agrochemical Research: Used in developing novel herbicides, fungicides, and plant growth regulators that leverage the tetrazole pharmacophore.
• Material Science: Serves as a monomer or cross-linking agent in the production of specialty polymers, coatings, and liquid crystal materials.
• Chemical Biology & Proteomics: Employed as a bioisostere for carboxylic acids in drug design and as a component in affinity chromatography ligands.
• Coordination Chemistry: Acts as a ligand for metal-organic frameworks (MOFs) and catalysts due to its nitrogen-rich tetrazole group.
• Academic & Contract Research: Essential for medicinal chemistry programs and custom synthesis projects in university and CRO laboratories.

Basic Information

Product Name	3-[4-(1H-Tetrazol-1-Yl)Phenyl]Propanoic Acid
CAS No.	924858-72-0
Molecular Formula	C10H10N4O2
Molecular Weight	218.21 g/mol
Synonyms	3-[4-(1H-Tetrazol-1-yl)phenyl]propionic acid; 4-(1H-Tetrazol-1-yl)benzenepropanoic Acid; 3-(4-(1H-Tetrazol-1-yl)phenyl)propanoic acid; 1-[4-(2-Carboxyethyl)phenyl]-1H-tetrazole; Valsartan Intermediate; Losartan Related Compound; Tetrazole Phenylpropanoic Acid Derivative; Benzenepropanoic acid, 4-(1H-tetrazol-1-yl)-
EINECS	Contact for details

Quality Control

Our 3-[4-(1H-Tetrazol-1-Yl)Phenyl]Propanoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and structural identity. We provide detailed Certificates of Analysis (COA) with each shipment, documenting purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and batch-to-batch consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.