Description

6-(4-Trifluoromethylphenyl)-Picolinic Acid is a specialized organic compound featuring a picolinic acid core substituted with a trifluoromethylphenyl group. This structure makes it a valuable high-purity building block and key intermediate in advanced chemical synthesis. It is primarily utilized by research institutions and industrial manufacturers engaged in the development of pharmaceuticals, agrochemicals, and functional materials where the introduction of the trifluoromethyl group is critical for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Serves as a key synthon for developing novel herbicides, fungicides, and insecticides, where the CF₃ group enhances lipophilicity and metabolic stability.
• Ligand in Catalysis: Used to construct complex ligands for transition metal catalysts in cross-coupling and other asymmetric synthesis reactions.
• Material Science: Employed in the research and development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-withdrawing characteristics.
• Chemical Biology Probe: Acts as a scaffold for creating molecular probes and inhibitors to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	6-(4-Trifluoromethylphenyl)-Picolinic Acid
CAS No.	924817-68-5
Molecular Formula	C₁₃H₈F₃NO₂
Molecular Weight	267.21 g/mol
Synonyms	6-[4-(Trifluoromethyl)phenyl]pyridine-2-carboxylic acid; 2-Pyridinecarboxylic acid, 6-[4-(trifluoromethyl)phenyl]-; 6-(4-Trifluoromethyl-phenyl)-picolinic acid; 6-(4-(Trifluoromethyl)phenyl)picolinic acid; 924817-68-5; 6-(p-Trifluoromethylphenyl)picolinic acid
EINECS	Contact for details

Quality Control

Our 6-(4-Trifluoromethylphenyl)-Picolinic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing including HPLC, NMR, and MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the stringent requirements for research and development and cGMP intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The product is stable under these conditions but should be kept away from strong acids and organic solvents. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.