Description

2-(2-Fluorophenyl)-Isonicotinic Acid is a high-purity fluorinated heterocyclic building block essential for advanced organic synthesis. This compound serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique structure imparts desirable biological and physicochemical properties. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of potential drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides that require fluorinated aromatic components for enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in catalytic processes and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of organic electronic materials and advanced polymers where fluorination improves stability and performance.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	2-(2-Fluorophenyl)-Isonicotinic Acid
CAS No.	924645-91-0
Molecular Formula	C12H8FNO2
Molecular Weight	217.20 g/mol
Synonyms	2-(2-Fluorophenyl)pyridine-4-carboxylic acid; 4-Pyridinecarboxylic acid, 2-(2-fluorophenyl)-; Isonicotinic acid, 2-(2-fluorophenyl)-; 2-(2-Fluorophenyl)-4-pyridinecarboxylic acid; 2-(o-Fluorophenyl)isonicotinic acid; 2-Fluoro-2'-pyridin-4-yl-biphenyl-4-carboxylic acid (related isomer); FPHIA (abbreviation)
EINECS	Contact for details

Quality Control

Every batch of 2-(2-Fluorophenyl)-Isonicotinic Acid is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing key parameters such as assay and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.